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Thrivee (Now Kaden) virtual medication assisted treatment


This document highlights supporting evidence to THRIVEE’s (now Kaden) use of technology to enable virtual delivery of Medication Assisted Treatment to treat Opioid Use Disorder. THRIVEE (now Kaden) combines virtual visits for medication maintenance with virtual group therapy using face-to-face video between patients and providers for a care experience that boosts access to care, increases retention and engagement, and is convenient and private. Supporting evidence highlights how Medication Assisted Treatment is the best care for addiction, that Virtual Medication Assisted Treatment improves access to care and increases retention and engagement, and how future regulations may better enable THRIVEE’s (now Kaden) delivery model. Medication Assisted treatment with buprenorphine is the current standard to treat Opioid Use Disorder in terms of clinical guidelines, patient preference, outcomes, quality, and cost. Virtual Medication Assisted treatment is optimizing the delivery model for telemedicine and has been shown in early studies to increase access to treatment with comparable outcomes. Current regulations require an initial in person medical evaluation prior to Virtual Medication Assisted Treatment yet may change with pending federal legislation as of June 2018.


Medication Assisted Treatment (MAT) combines psychotherapy and pharmacotherapy to treat Opioid Use Disorder (OUD). The main pharmacotherapy agents for treating OUD are buprenorphine and methadone as part of American Society of Addiction Medicine (ASAM) guidelines. Both buprenorphine and methadone are considered essential medicines by the World Health Organization. Buprenorphine is considered equally effective to methadone according to a 2016 meta-analysis of 27 randomized controlled trials. Studies of patient preference have indicated more positive attitudes toward buprenorphine because of ease of access, convenience , and reduced stigma compared to methadone. Combined buprenorphine and naloxone has demonstrated adherence, efficacy, safety, and tolerability in patients with prescription OUD. In addition, buprenorphine reduces the risk of adverse events compared to methadone. A 5-year study (2008-2013) of over 8,000 Vermont Medicaid beneficiaries indicated cost savings with MAT (combining patients prescribed buprenorphine and methadone) in terms of reduced admissions and emergency department visits. The findings suggest, that even for Medicaid enrollees, MAT improves outcomes and reduces spending compared to usual care of counseling and detoxification.


Early studies of telemedicine (ie virtual) Medication Assisted Treatment (VMAT™) have shown promising results for improved treatment outcomes and expanding access. A study of 3,733 patients enrolled in MAT conducted in Ontario Canada across 58 clinics from 2011-2012 identified increased year one retention via telemedicine (50%) versus in person (39%). An update by the same research group studied access using a 2008 to 2014 retrospective cohort of 9,077 patients provincially insured in Ontario Canada receiving VMAT™. The study identified 55% of patients enrolled in VMAT™ had a concurrent mental health disorder and more frequent use of VMAT™ by patients in rural regions of the province. The authors findings reinforced previous studies that suggest telemedicine addressed geographic barriers to access to patients with OUD and behavioral health concerns and is “effective to patient, provider and society as a whole.”10 A retrospective review of 100 patients enrolled in MAT from 2013 to 2014 identified no significant difference in terms of treatment retention, abstinence, and additional substance use. Additional benefits of VMAT™ include privacy and anonymity thus avoiding stigmatization of addiction and psychiatric treatment.


The largest barrier to telemedicine (i.e. virtual) medication assisted treatment (VMAT™) as of June 2018 remains provisions of the Ryan Haight Act which amended the Controlled Substances Act (21 CFR). Named after a teenager who died of a drug overdose after obtaining Vicodin from an online pharmacy without evaluation by a provider, the legislation restricted the dispensing of controlled substances using the internet. As a result, providers are required to conduct at least one face-to-face encounter for an initial medical evaluation. As of June 2018, multiple proposed new legislative efforts seek to change policy to increase patient access to VMAT™ via expanding telehealth delivery options such as waiving current restrictions for face to face encounters thus enabling telehealth (i.e. virtual care) and enhancing access with new funding mechanisms for patients. Telehealth parity laws enable VMAT™ requiring that health insurers cover and pay for services delivered via telehealth the same as if delivered in-person. As of June 2018, telehealth parity laws have been enacted in 35 states and the District of Columbia.